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High Absorption 5-HTP - 200mg


3 Months Supply "... Soothe your body and mind. Our high-strength formula contains an astounding 200mg of 5-HTP plus other ingredients that enhance mood, reduce anxiety, decrease appetite, and improve sleep. " New Page 1


5-HTP 5-HTP works to increase serotonin levels in the brain, which in turn alleviates anxiety and stress, reduces depression, and promotes better sleep patterns.   
5-HTP (5-Hydroxytryptophan) is produced by the human body from the amino acid L-tryptophan (LT), which is found in dietary proteins. 5-HTP is converted in the brain to serotonin, a chemical that plays an important role in mood, appetite, and sleep. Low serotonin levels can cause a host of problems, including depression, mood swings, sleep difficulties, and increased appetite. To raise the body's serotonin levels, it is necessary to supplement the body's supply of 5-HTP. With 200mg of 5-hydroxytryptophan, Pureclinica's 5-HTP has one of the strongest formulas available today. In addition, it contains Vitamins B6 and C, which are essential vitamin co-factors in the conversion of tryptophan to serotonin. Because the ingredients in Pureclinica's 5-HTP are all natural, there are none of the harmful and unpleasant side effects that can accompany the use of prescription medications for depression and similar health problems.
With the help of scientific and medical research, we have developed extensive knowledge about the importance of 5-HTP and its effect on serotonin levels in the human brain. With this information in mind, Pureclinica have created a natural daily supplement that safely and effectively helps to increase serotonin levels, thereby reducing or eliminating problems such as depression, mood swings, anxiety, insomnia, obesity, and migraine and tension headaches. Pureclinicas 5-HTP provides a high-strength, high-absorption formula that is formulated to help improve overall mood and health by increasing the serotonin levels in the brain. Each tablet contains 200mg of 5-hydroxytryptophan, supplying your body with the necessary ingredients to create ample levels of serotonin in your brain. In addition, Pureclinicas 5-HTP contains the patented product Bioperine, which aids in the bioavailability of all of its ingredients.
Low serotonin levels can be caused by several factors, including not eating enough protein, digestive problems, and insufficient intake of certain vitamins. Evidence shows that low serotonin levels are often a result of modern lifestyle and dietary practices. Many people today have lowered levels of serotonin in their brains, which can lead to depression, headaches, muscle aches, obesity, and a craving for carbohydrates. Fortunately, these health problems can be remedied by increasing the serotonin levels in the brain. In order to boost serotonin production, it is necessary to supplement the body's supply of 5-hydroxytryptophan, because it is the link between tryptophan and serotonin. In other words, tryptophan leads to the production of 5-HTP which the body then converts to serotonin. There are only two places where 5-HTP can be found in nature: in the human body and in the seeds of the African plant Griffonia simplicifolia. Pureclinica's 5-HTP uses the finest quality commercially produced 5-HTP, in a high-strength formula, to help ensure that your body has all the serotonin necessary for optimal health and functioning.


Serving Size: 1 caplet
Per 1 Caplet:
200mg 5-HTP
200mg Vitamin C
5mg Bioperine
15mg Vitamin B6 (Pyridoxine hydrochloride)

Ingredients Information

5-HTP (5-Hydroxytryptophan) is made by the body from the amino acid L-tryptophan (LT). 5-HTP is then converted to serotonin, a chemical that plays a vital role in behaviour, mood, appetite, and sleep. Besides the human body, the only other natural source of 5-HTP is the plant Griffonia simplicifolia. Made from the highest-quality commercially produced 5-hydroxytryptophan, Pureclinica's 5-HTP helps your body create all the serotonin required to achieve optimal health and well-being.
Vitamin C
Also known as ascorbic acid, Vitamin C is a water-soluble vitamin that works as an extremely effective antioxidant. Vitamin C's medical uses include the prevention of scurvy, and it has been shown to help improve or inhibit conditions such as heart disease, cancer, cataracts, hypertension, and the common cold. Human beings cannot manufacture their own vitamin C, so they must get it through their diets or by supplementation. Without the presence of Vitamin C, the body is not able to convert 5-HTP to serotonin.
Bioperine is manufactured by the award-winning Sabinsa Corporation, and it is the only product made from piperine to be patented for its ability to increase bioavailability. Bioperine is extracted from Piper nigrum L (black pepper) or Piper longum L (long pepper). It is composed of 95% piperine, the strong substance found in the plants. Bioperine works to increase the bioavailability of nutritional compounds. It can manipulate metabolic conversion and assisted absorption, which allows more substances to enter the body in active form. As a result, Bioperine enables the other ingredients in Pureclinica's 5-HTP to arrive at, enter, and stay in the targeted cells.
Vitamin B6 (Pyridoxine hydrochloride)
Because the human body cannot manufacture Vitamin B6 (Pyridoxine hydrochloride), it must be obtained from the diet or from supplementation. This vitamin is essential for the functioning of about 100 enzymes that catalyze vital chemical reactions. Vitamin B6 has been used in the treatment of various medical conditions, including cardiovascular disease, impaired cognitive and immune function, depression, premenstrual syndrome (PMS), and morning sickness. In the brain, Vitamin B6 is required for the creation of serotonin from the amino acid tryptophan.


Take 1 caplet daily with a glass of water. For best results take on an empty stomach.


Pureclinica's 5-HTP contains 200mg of 5-hydroxytryptophan, 5mg of Bioperine, 200mg of Vitamin C, and 15mg of Vitamin B6  a  much higher-strength formula than almost all other 5-HTP supplements available on the market today. In fact, Pureclinica's 5-HTP contains twice as much 5-HTP as Best 5-HPT (made by Doctor's Best), Serotone 5HTP (produced by Higher Nature), and Happy Days 5-HTP Supplement (manufactured by Healthspan). In addition, none of these products have Bioperine, the award winning patented nutrient that increases the bioavailability of other ingredients. Higher Nature is also missing Vitamin C from its list of ingredients, while Doctor's Best lacks both vitamins C and B6, which are necessary for converting 5-HTP to serotonin. While Pureclinica's prices may be slightly higher than some of our competitors, it is important to remember that our product is twice as strong as the others  thereby offering a far better value for your money. For increased savings, buy our 180-day supply of 5-HTP rather than the 90-day supply. Pureclinica's 5-HTP is a powerful, high-quality, high-absorption supplement that works safely, effectively, and efficiently to increase serotonin levels in the brain.


1.What is 5-HTP by Pureclinica?
5-HTP by Pureclinica is a supplement designed to elevate mood and overall feelings of well-being by increasing the levels of serotonin in the brain. It works to alleviate anxiety and stress, reduce depressive symptoms, decrease appetite, and promote better sleep patterns.

2.What makes 5-HTP by Pureclinica superior to other 5-HTP supplements?
Pureclinica's 5-HTP has a scientifically developed, high-strength formula that is not found in our competitors products. Our product contains 200mg of 5-hydroxytryptophan, one of the most powerful strengths on the market. In addition, Pureclinica's 5-HTP is enhanced with Vitamin B6, Vitamin C, and Bioperine.

3.Exactly what is Bioperine and what does it do?
Bioperine, manufactured and patented by the award-winning Sabinsa Corporation, is an extract taken from certain pepper plants that works to increase the bioavailability of nutritional compounds. Bioavailability describes how much of a substance enters the bloodstream and reaches the site of action. Bioperine is able to manipulate metabolic conversion and assisted absorption, which allows more substances to enter the body in active form and reach the targeted areas. That means that Bioperine ensures that the maximum potential of all the ingredients in Pureclinica's 5-HTP are available for use.

4.Is 5-HTP safe to use?
5-HTP is safe to use by most people. However, if you are currently taken antidepressants (including SSRIs, tricyclics, MAOIs, and Nefazodone), Carbidopa, Tramadol, or any of the Triptans for migraines, then you should not take 5-HTP. In addition, children, pregnant women, nursing mothers, and those with liver disease should not take 5-HTP supplements.

5.Does 5-HTP have any known side effects?
Some mild side effects have been associated with the use of 5-HTP, usually gastrointestinal complaints such as nausea, heartburn, and flatulence. Some people also report drowsiness when first taking 5-HTP, which disappears after repeated use. If 5-HTP is taken at very high doses, a dangerous condition known as serotonin syndrome could develop. You should therefore consult a physician before taking 5-HTP in doses higher than what is recommended.

6.How much do I take and how often?
Take 1 tablet of Pureclinica's 5-HTP once per day.

7.Who should take Pureclinica's 5-HTP?
Pureclinica's 5-HTP is recommended for people suffering from the effects of low serotonin levels or from conditions such as depression, sleep disturbances, migraines, PMS, eating disorders, and fibromyalgia.

8.How long does it take for the benefits of 5-HTP to take effect?
This varies from person to person. Some people report almost immediate results. For most people, the effects will be felt within 1-7 days.

9.How is 5-HTP sold?
5-HTP is sold in packages of 90 caplets (a 3-month supply) and 180 caplets (a 6-month supply) at 200mg strength.

10.Is Pureclinica's 5-HTP less expensive than similar supplements?
While the cost for a bottle of Pureclinica's 5-HTP may be slightly higher than similar products, it is important to remember that our product is of the finest quality, with a high-absorption formula that is twice as strong as many of our competitors  giving you better quality and a better value for your money. Furthermore, a bottle of Pureclinica Higher Absorption 5-HTP will last for 3 months so offers significantly better value for money than the 1 months supply typically offered by other brands. For increased savings, buy our 180-day supply of 5-HTP rather than the 90-day supply.

Clinical Studies

Research has demonstrated that people who take 5-HTP supplements often experience reduced anxiety, decreased appetite, enhanced mood, and improved sleep patterns. Many clinical studies have been conducted investigating the beneficial health effects of supplementing the diet with 5-HTP, particularly in people suffering from depression. Other studies have focused on the effect of 5-HTP supplementation on people who suffer from migraine headaches, fibromyalgia, obesity, and sleep disturbances. 
    In a 6-week clinical trial, 63 people were given either 5-HTP or an antidepressant (fluvoxamine). The 5-HTP was found to be as effective as the antidepressant, but without as many side effects.(1)
    In another study, 99 outpatients who suffered from depression and who did not respond to drug therapies were treated with 5-HTP. The participants received about 200mg of 5-HTP each day. Over 50% of the patients showed improvement from this treatment, with 43 of them reporting complete recovery and another 8 reporting great improvement in their symptoms. None of the patients experienced side effects.(2)
    Research shows that 5-HTP may be beneficial in preventing migraines and in lessening their frequency and severity. One study, in which 124 participants were given either 5-HTP or the drug methysergide for 6 months, demonstrated that 5-HTP was as effective as methysergide in reducing the severity and duration of migraines.(3)
    A placebo-controlled, double-blind study investigated 50 fibromyalgia patients who were given either 5-HTP or a placebo. After 1 month, the participants noticed  improvement in many of their symptoms, including pain, stiffness, tiredness, anxiety, and sleep disturbances.(4)
    In a double-blind study, 20 obese patients were given either 5-HTP or a placebo. Significant weight loss, a reduction in carbohydrate intake, and a feeling of  satiety were found in the participants who received 5-HTP. In addition, 5-HTP was well tolerated by the patients. These results suggest that 5-HTP may be safely and effectively used to treat obesity.(5) 
    In numerous studies, the use of 5-HTP has demonstrated its effectiveness in reducing the time required to fall asleep and to decrease the number of times a person wakes up.(6)
The results from these and other studies have proven conclusively that taking 5-HTP as a daily supplement can help
to increase serotonin levels in the brain and that such an increase leads to a decrease in the levels of anxiety and stress, reduces depression, suppresses the appetite, and encourages more restful sleep. Pureclinicas 5-HTP high-strength, high-absorption tablets contain 200mg of 5-Hydroxytryptophan, a dose strong enough to supply your body with everything it needs to create the vital neurotransmitter serotonin. With the addition of Bioperine to the formula, Pureclinica Higher Absorption 5-HTP ensures that the maximal amount of 5-HTP will be absorbed by your body. 
1. Poldinger W., B. Calanchini and W. Schwarz. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology. 1991. Vol. 24; No. 2: pp. 53-81.
2. van Hiele, L.J. L-5-Hydroxytryptophan in Depression: The First Substitution Therapy in Psychiatry? The Treatment of 99 Out-Patients with 'Therapy-Resistant' Depressions. Neuropsychobiology. 1980. Vol. 6; No. 4: pp. 230-240.
3. Titus F., A. Davalos, J. Alom et al. 5-hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol. 1986. Vol. 25; pp. 327-329.
4. Caruso I., P. Sarzi Puttini, M. Cazzola and V. Azzolini. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. 1990. Vol. 18; No. 3: pp. 201-209.
5. Cangiano, C., F. Ceci, A. Cascino et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. American Journal of Clinical Nutrition. 1992. Vol 56; pp. 863-867.
6. The effect of 5-HTP on sleep patterns. Brain Research. 1976. Vol. 106; pp. 106-115.

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This product was added to our catalog on Sunday 12 June, 2011.

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